February 21, 2006
Selexis SA Presented New Data on MARtech™ at
the BioProcess International, European
Conference and Exhibition
Patented Technology Significantly
Improves the Stability of Production Cell Lines
Geneva, Switzerland – February 21, 2006 –
Selexis SA, a Swiss-based biotechnology company
specializing in high yield and stable cell line
development for therapeutic proteins announced
new MARtech™ data from FISH analysis of CHO cell
lines expressing recombinant proteins was
presented today. The data which was presented
during the “BioProcess International, European
Conference and Exhibition” in Prague,
demonstrated that, with MARtech™, transgenes are
integrated in a single site on the chromosome
within regions of the chromatin that have been
shown to be very stable.
The data are results from an ongoing
collaboration between Selexis and Dr. Danielle
Martinet from the University Hospital in
Lausanne under the supervision of Prof. Nicolas
Mermod from the University of Lausanne,
Switzerland.
“Contrary to traditional approaches for
developing mammalian cell lines, we now know
that, in contrast to DHFR, MARtech™ is not
associated with chromosomal rearrangements nor
chromosomal breaks,” said Igor Fisch, Ph.D.,
President and Chief Executive Officer of Selexis.
“This is a significant step forward in the
development of stable, high producing mammalian
cell lines. The Selexis’ approach to the
development of cell lines has shown that the
transgene integrates into a single site within
the host cell chromosome. MARtech™ routinely
results in cell clones expressing over 50 pcd of
recombinant monoclonal antibodies within 8 weeks
after transfection.”
“The results are an important validation of
the mechanism by which Selexis’ MARtech™
functions. The chromosomal characterization of
our cell lines by FISH shows a very simple
pattern of integration which allows MARtech™
production cell lines to be easily analyzed for
regulatory approval,” adds Cori Gorman, Ph.D.,
M.B.A., Head of Business Development. “The data
further demonstrates our commitment to the
biopharmaceutical industry for the development
of high-quality cell lines for manufacturing.”
Dr. Gorman, presented these FISH data today
as part of the Cell Culture and Upstream
Processing track.
More About MARtech™
Selexis' patented technology, MARtech™,
improves the speed, yield and stability of
production cell lines used for therapeutic
protein manufacturing. MARtech™ allows fast cell
population generation in 3 weeks (after
transfection) and stable cell line development
in 8 weeks (after transfection to first round of
cell cloning). Additionally, MARtech™ has been
found to increase recombinant protein expression
in mammalian cells in suspension and in
serum-free more than 10 fold.
About Selexis
Selexis is a privately held biotechnology
company dedicated to the development of expert
services and technologies for comprehensive and
rapid solutions for stable, high yield cell line
Selexis SA to Present New Data on MARtech™
development and protein manufacturing for
therapeutic drugs. The Company’s unique seven
step, high through put process, which includes
the forth generation patented MARtech™, reduces
traditional cell line development (DHFR) from 12
months to 3 months (after transfection to
isolating cell clones) without any change in the
scale-up process. For more information please
visit
http://www.selexis.com
About BioProcess International, European
Conference and Exhibition
BioProcess International Conference and
Exhibition is a collaboration between IBC’s four
successful biopharmaceutical development
conferences and BioProcess International, the
first and only international publication devoted
to the development, scale-up, and manufacture of
biotherapeutics and biodiagnostics. The
conference is the premier event for a
comprehensive update on operational strategies,
technologies, regulatory changes, manufacturing
production, and process development. The
conference consists of four in-depth tracks: 1 -
Scaling-up, Economics and Manufacturing
Strategies; 2 - Formulation & Drug Delivery; 3 -
Cell Culture & Upstream Processing; and 4 -
Recovery & Purification. For more information,
please visit
http://www.ibc-lifesci.com/bpi/2006
This news release contains forward-looking
statements that involve a number of known and
unknown risks and uncertainties. Forward-looking
statements are often signaled by forms of words
such as should, could, will, might, plan,
projection, forecast, expect, guidance,
potential and developing. These statements are
only predictions and actual events or results in
future periods may differ materially from what
is currently anticipated. In particular, we
cannot assure you that we will be able to
successfully develop or commercialize products
based on our technology, particularly in light
of the significant uncertainty inherent in
developing drug delivery products, conducting
clinical trials and obtaining regulatory
approvals, that our technologies will prove to
be safe and effective, that our joint ventures
or our collaborations with other companies in
the U.S. and abroad will successfully develop
products or become profitable, that our business
strategy will be successful or that we will be
able to carry out our plans for 2007.
MARtech™ is a trademark of Selexis, SA.
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